The issue of providing the population with affordable housing is one of the most pressing social concerns. Each region necessitates a distinct approach. The purpose of this article is to identify the factors that influence a housing affordability level in the region, analyze the impact mechanisms inherent in them, and assess the quantitative impact of these factors on the housing affordability index. The following factors have a direct impact on housing affordability: the rate of inflation, the population size, the cost of housing, the loan interest rate, the rate of housing construction, the investment scale, the income level of the population, and the economic system’s overall development level. The quantitative assessment of the cumulative impact of these factors on the level of housing affordability is based on building a regression model describing how the housing affordability index in the region depends on multiple factors and assessing its reliability. The simulation model confirmed that the supply, demand, and housing market conditions have the greatest impact on housing affordability in the region