Vietnam successfully controlled the COVID-19 pandemic in the initial periods through public health and social measures. However, the country endured a severe crisis in the next stage and had to change its strategies by focusing on vaccination and stricter measures. As a result, the vaccination rate rapidly increased, and the COVID-19 pandemic has become endemic since April 2022. Two thresholds emerged to change the pandemic into a new stage when indicators and conditions reach certain levels. The main lessons can be withdrawn from Vietnam as follows: collecting sufficient data and information; combining different strategies and suitable measures; identifying thresholds of the pandemics; balancing trade-offs; promoting effective communication; and developing science, vaccines, and vaccination.